coli proved not to react in the same way to specific antibiotic combinations. coli bacteria isolated from urinary tract infections. In their study, the researchers investigated E. On the agar plate, bacteria that have been isolated from an individual patient are then cultured to see how they react to different combinations of antibiotics. It is based on creating a "concentration gradient" of antibiotics that have been cast into an agar plate, using a 3D-printed plastic disc. The lead author of the study, Nikos Fatsis-Kavalopoulos, developed the method at Uppsala University. With the newly developed method known as CombiANT (combinations of antibiotics), interactions between various antibiotics can be tested on agar plates and results obtained in 24 hours. However, knowing what the combined effect will be is not always easy. In contrast, the opposite phenomenon - that is, two antibiotics counteracting each other's effects ("antagonism") - is undesirable. The effect sought, "synergism", means that the joint action of the combined agents is more effective than could in fact have been expected, based on the efficacy of the separate agents. Bacterial infections that are not readily treatable, such as those affecting cardiac valves and prostheses, and lung infections in cystic fibrosis, are also usually subjected to a combination of antibiotics. The new method is simple for laboratories to use and can provide greater scope for customising treatment of bacterial infections.Ĭombinations of antimicrobial agents are invariably prescribed for certain infectious diseases, such as tuberculosis, HIV and malaria. Researchers at Uppsala University have developed a new method to determine - rapidly, easily and cheaply - how effective two antibiotics combined can be in stopping bacterial growth.
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